With a rural place name from Agrius, this village is mentioned in 1057 in a donation to the Abbey of Farfa.

Today Agriano shows characteristics of a village, divided into three distinct parts, the oldest of which shows some aspects of a particularly compact mediaeval town. The central part is without doubt the part that has changed the most, whereas the eastern part contains several 18th century mansions. Rebuilding and recent development indicates an economy based on agricultural activities that continue to flourish.

Agriano is named in the statutes of Norcia as a late mediaeval castle named Grigliano or Griiano.

The church of San Vito is mentioned in the parish of Avendita. During the construction of the road from Agriano to Avendita during the period from 1930-40 on the site of the current primary school, some ancient tombs came to light, the contents of which were lost and destroyed. Opposite the church of San Vito on the left-hand side of the gate to the house of the Ruggeri family stands a white, marble, Roman tombstone. A prominent feature of the village is the mansion, Casa Lalli (1645), built by the family of the poet Giovan Battista who owned property here.